Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Belongs to the peptidase C19 family. UBP8 subfamily.
Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver.
Proteins
Epigenetics
59961Da
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ab314177
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