USP31
Function
Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. May play a role in the regulation of NF-kappa-B signaling pathway by deubiquitinating TRAF2.
(Microbial infection) Plays a positive role in foot-and-mouth disease and classical swine fever viral infection. Mechanistically, associates with internal ribosomal entry site (IRES) element within the 5'-untranslated region of viral genomes to promote translation of the virus-encoded polyprotein.
Post-translational modifications
Acetylated at Lys-1264. Acetylation decreases activity. Deacetylated by SIRT1.
Sequence Similarities
Belongs to the peptidase C19 family.
Tissue Specificity
Widely expressed.
Alternative names
KIAA1203, USP31, Ubiquitin carboxyl-terminal hydrolase 31, Deubiquitinating enzyme 31, Ubiquitin thioesterase 31, Ubiquitin-specific-processing protease 31