USP32
Function
Deubiquitinase that can remove conjugated ubiquitin from target proteins, such as RAB7A and LAMTOR1 (PubMed:36476874). Acts as a positive regulator of the mTORC1 signaling by mediating deubiquitination of LAMTOR1, thereby promoting the association between LAMTOR1 and the lysosomal V-ATPase complex and subsequent activation of the mTORC1 complex (PubMed:36476874).
Sequence Similarities
Belongs to the peptidase C19 family.
Cellular localization
- Golgi apparatus membrane
- Lipid-anchor
Alternative names
USP10, USP32, Ubiquitin carboxyl-terminal hydrolase 32, Deubiquitinating enzyme 32, Renal carcinoma antigen NY-REN-60, Ubiquitin thioesterase 32, Ubiquitin-specific-processing protease 32