USP35
Function
Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress (PubMed:26348204, PubMed:29449677, PubMed:37004621). Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination (PubMed:26348204). Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein (PubMed:29449677). In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability (PubMed:34438346). Regulates the degradation of mitochondria through the process of autophagy termed mitophagy (PubMed:25915564).
Post-translational modifications
Ubiquitinated by CHIP/STUB1 in an HSP90-dependent manner; leading to proteasomal degradation. This ubiquitination can be reversed through auto-deubiquitinating activity.
Sequence Similarities
Belongs to the peptidase C19 family.
Tissue Specificity
Expressed in testis, pancreas and skeletal muscle.
Cellular localization
- Cytoplasm
- Mitochondrion
- Only associates with polarized mitochondria, and rapidly translocates to the cytosol during mitophagy.
Alternative names
KIAA1372, USP34, USP35, Ubiquitin carboxyl-terminal hydrolase 35, Deubiquitinating enzyme 35, Ubiquitin thioesterase 35, Ubiquitin-specific-processing protease 35