USP46

Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:19075014, PubMed:26388029). Not involved in deubiquitination of monoubiquitinated FANCD2 (PubMed:19075014).

Belongs to the peptidase C19 family. USP12/USP46 subfamily.

Broadly expressed.

• Cytoplasm
• USP46/WDR48/WDR20 complex is predominantly cytoplasmic.

Ubiquitin carboxyl-terminal hydrolase 46, Deubiquitinating enzyme 46, Ubiquitin thioesterase 46, Ubiquitin-specific-processing protease 46, USP46

• entrezGene:64854
• omim:612849
• swissprot:P62068

Proteins

42442Da