UST
Function
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin.
Sequence Similarities
Belongs to the sulfotransferase 3 family.
Tissue Specificity
Widely expressed.
Cellular localization
- Golgi apparatus membrane
- Single-pass type II membrane protein
Alternative names
DS2ST, UST, Uronyl 2-sulfotransferase