UTP18

Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA.

Belongs to the WD repeat UTP18 family.

• Nucleus
• Nucleolus

WDR50, CDABP0061, CGI-48, UTP18, U3 small nucleolar RNA-associated protein 18 homolog, WD repeat-containing protein 50

• entrezGene:51096
• omim:612816
• swissprot:Q9Y5J1

Proteins

Metabolism

62004Da