UTP20
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in 18S pre-rRNA processing. Associates with U3 snoRNA.
Sequence Similarities
Belongs to the UTP20 family.
Tissue Specificity
Expressed in appendix, brain, colon, fetal liver, heart, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
Cellular localization
- Nucleus
- Nucleolus
- Colocalizes with NCL in the nucleolus.
Alternative names
DRIM, UTP20, Small subunit processome component 20 homolog, Down-regulated in metastasis protein, Novel nucleolar protein 73, Protein Key-1A6, NNP73