UTRN

Domain

Actin binding affinity is primarily determined by CH domain 1.

Function

May play a role in anchoring the cytoskeleton to the plasma membrane.

Tissue Specificity

Isoform 1 has high expression in muscle. Isoforms Up70 and Up140 were found in all the adult and fetal tissues tested and relatively abundant in lung and kidney.

Cellular localization

• Postsynaptic cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cytoplasm
• Cytoskeleton
• Neuromuscular junction.

Alternative names

DMDL, DRP1, UTRN, Utrophin, Dystrophin-related protein 1, DRP-1

Database links

swissprot:P46939 entrezGene:7402 omim:128240 swissprot:Q5T097 swissprot:Q5SZ57