UXS-1

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose (PubMed:22810237, PubMed:23656592, PubMed:25521717). Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (PubMed:22810237, PubMed:23656592, PubMed:25521717).

Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.

Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

• Golgi apparatus
• Golgi stack membrane
• Single-pass type II membrane protein

UNQ2538/PRO6079, UXS1, UDP-glucuronic acid decarboxylase 1, UDP-glucuronate decarboxylase 1, UGD, UXS-1, hUXS, hUXS1

• entrezGene:80146
• omim:609749
• swissprot:Q8NBZ7

Proteins

Oncology

47577Da