vacA
Domain
The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity).
Function
Induces vacuolation of eukaryotic cells. Causes ulceration and gastric lesions.
Cellular localization
- Vacuolating cytotoxin autotransporter
- Periplasm
- Vacuolating cytotoxin
- Secreted
- Cell surface
- Vacuolating cytotoxin translocator
- Cell outer membrane
- Multi-pass membrane protein
- The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
Alternative names
HP_0887, vacA, Vacuolating cytotoxin autotransporter