Vacuolar protein sorting-associated protein 37B
Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Sequence Similarities
Belongs to the VPS37 family.
Tissue Specificity
Widely expressed. Expressed in macrophages and lymphocytes.
Cellular localization
- Late endosome membrane
- Peripheral membrane protein
- Recruited to the endosomal membrane in a VPS4A-dependent fashion.
Alternative names
Vacuolar protein sorting-associated protein 37B, hVps37B, ESCRT-I complex subunit VPS37B, VPS37B