Vamp1
Function
Involved in the targeting and/or fusion of transport vesicles to their target membrane.
Post-translational modifications
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 61-Lys-|-Leu-62 bond and inhibits neurotransmitter release (PubMed:8175689). This is a poor substrate for BoNT/D, high concentrations are required to cleave it in vitro (PubMed:8175689).
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 60-Gln-|-Lys-61 bond and inhibits neurotransmitter release (PubMed:8505288).
Sequence Similarities
Belongs to the synaptobrevin family.
Tissue Specificity
Expressed in brain and spleen (at protein level). Isoform 1 expressed at very high level in brain. Even higher level found in spinal cord. Isoform 3 expressed in kidney, spleen and liver. Isoforms 2 and 3 expressed in osteoblasts of trabecular bone. Also expressed in heart.
Cellular localization
- Isoform 1
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle membrane
- Single-pass type IV membrane protein
- Synapse
- Synaptosome
- Isoform 2
- Cytoplasmic vesicle membrane
- Single-pass type IV membrane protein
- Isoforms 2 and 3 are found in perinuclear as well as peripheral punctate structures in osteoblasts.
- Isoform 3
- Mitochondrion outer membrane
- Single-pass type IV membrane protein
- Isoforms 2 and 3 are found in perinuclear as well as peripheral punctate structures in osteoblasts.
Alternative names
Syb1, Vesicle-associated membrane protein 1, VAMP-1, Synaptobrevin-1