Vamp2
Function
Involved in the targeting and/or fusion of transport vesicles to their target membrane (PubMed:9430681). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (PubMed:15475946). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity).
Post-translational modifications
Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB); 20 hours after treatment of spinal cord cells almost all the protein has been digested (PubMed:10413679). BoNT/B hydrolyzes the 76-Gln-|-Phe-77 bond and inhibits neurotransmitter release (Probable).
(Microbial infection) Targeted and hydrolyzed by C.tetani toxin (tetX); 20 hours after treatment of spinal cord cells almost all the protein has been digested (PubMed:10413679). Tetanus toxin hydrolyzes the 76-Gln-|-Phe-77 bond and inhibits neurotransmitter release (Probable).
Sequence Similarities
Belongs to the synaptobrevin family.
Tissue Specificity
Expressed in the outer plexiform layer of the retina (at protein level).
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Synaptic vesicle membrane
- Single-pass type IV membrane protein
- Cell membrane
- Colocalizes with PRKCZ and WDFY2 in intracellular vesicles.
Alternative names
Syb2, Vamp2, Vesicle-associated membrane protein 2, VAMP-2, Synaptobrevin-2