Cellubrevin

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Ubiquitinated by RNF167 at Lys-66, Lys-68 and Lys-77, regulating the recycling endosome pathway.

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).

Belongs to the synaptobrevin family.

• Early endosome membrane
• Single-pass type IV membrane protein
• Recycling endosome membrane
• Single-pass type IV membrane protein
• Synapse
• Synaptosome

SYB3, VAMP3, Vesicle-associated membrane protein 3, VAMP-3, Cellubrevin, Synaptobrevin-3, CEB

• entrezGene:9341
• omim:603657
• swissprot:Q15836

Proteins

Neuroscience

11309Da