VAMP3
Function
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Post-translational modifications
Ubiquitinated by RNF167 at Lys-66, Lys-68 and Lys-77, regulating the recycling endosome pathway.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB) which hydrolyzes the 59-Gln-|-Phe-60 bond and probably inhibits neurotransmitter release (PubMed:22289120).
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type D (BoNT/D, botD) which hydrolyzes the 42-Lys-|-Leu-43 bond and probably inhibits neurotransmitter release (PubMed:22289120). Note that humans are not known to be infected by C.botulinum type D.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type F (BoNT/F, botF) which hydrolyzes the 41-Gln-|-Lys-42 bond and probably inhibits neurotransmitter release (PubMed:22289120).
Sequence Similarities
Belongs to the synaptobrevin family.
Cellular localization
- Early endosome membrane
- Single-pass type IV membrane protein
- Recycling endosome membrane
- Single-pass type IV membrane protein
- Synapse
- Synaptosome
Alternative names
SYB3, VAMP3, Vesicle-associated membrane protein 3, VAMP-3, Cellubrevin, Synaptobrevin-3, CEB