Vamp3
Function
SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
Post-translational modifications
Ubiquitinated by RNF167 at Lys-70, Lys-72 and Lys-81, regulating the recycling endosome pathway.
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 53-Arg-|-Ala-54 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.
Sequence Similarities
Belongs to the synaptobrevin family.
Cellular localization
- Early endosome membrane
- Single-pass type IV membrane protein
- Recycling endosome membrane
- Single-pass type IV membrane protein
- Synapse
- Synaptosome
Alternative names
Syb3, Vamp3, Vesicle-associated membrane protein 3, VAMP-3, Cellubrevin, Synaptobrevin-3, CEB