Cellubrevin

SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.

Ubiquitinated by RNF167 at Lys-70, Lys-72 and Lys-81, regulating the recycling endosome pathway.

(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 53-Arg-|-Ala-54 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.

Belongs to the synaptobrevin family.

• Early endosome membrane
• Single-pass type IV membrane protein
• Recycling endosome membrane
• Single-pass type IV membrane protein
• Synapse
• Synaptosome

Syb3, Vamp3, Vesicle-associated membrane protein 3, VAMP-3, Cellubrevin, Synaptobrevin-3, CEB

• swissprot:P63024

Proteins

Neuroscience