VAMP5
Function
May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking.
Post-translational modifications
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type X (BoNT/X) which hydrolyzes the 40-Arg-|-Ser-41 bond and probably inhibits neurotransmitter release (PubMed:28770820). It remains unknown whether BoNT/X is ever produced, or what organisms it targets.
Sequence Similarities
Belongs to the synaptobrevin family.
Cellular localization
- Cell membrane
- Single-pass type IV membrane protein
- Endomembrane system
- Single-pass type IV membrane protein
- Golgi apparatus
- trans-Golgi network membrane
- Single-pass type IV membrane protein
- Associated with the plasma membrane as well as intracellular perinuclear and peripheral vesicular structures of myotubes. Associated with the trans-Golgi, but not with the cis-Golgi apparatus (By similarity).
Alternative names
HSPC191, VAMP5, Vesicle-associated membrane protein 5, VAMP-5, Myobrevin