VASN
Function
May act as an inhibitor of TGF-beta signaling.
Post-translational modifications
N-glycosylated. N-glycan heterogeneity at Asn-117: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor).
Tissue Specificity
Expressed at highest levels in aorta, at intermediate levels in kidney and placenta and at lowest levels in brain, heart, liver, lung and skeletal muscle. Within the aorta, the strongest expression is found in the tunica media of the proximal ascending aorta, the descending thoracic aorta, the abdominal aorta and the coronary arteries. Within the kidney, expression is found in the interstitial cells.
Cellular localization
- Membrane
- Single-pass type I membrane protein
- Secreted
Alternative names
SLITL2, UNQ314/PRO357/PRO1282, VASN, Vasorin, Protein slit-like 2