Vasoactive intestinal polypeptide receptor 1
Function
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38.
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family.
Tissue Specificity
In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T-cell lines Peer, MOLT-4, HSB and YT.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Vasoactive intestinal polypeptide receptor 1, VIP-R-1, Pituitary adenylate cyclase-activating polypeptide type II receptor, VPAC1, PACAP type II receptor, PACAP-R-2, PACAP-R2, VIPR1