VAT1
Function
Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).
Sequence Similarities
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Tissue Specificity
Expressed in brain. Also expressed in glioblastoma cells.
Cellular localization
- Cytoplasm
- Mitochondrion outer membrane
- Peripheral membrane protein
- The majority is localized in the cytoplasm and a small amount is associated with mitochondria.
Alternative names
Synaptic vesicle membrane protein VAT-1 homolog, VAT1