VAV1
Domain
The DH domain is involved in interaction with CCPG1.
Function
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Post-translational modifications
Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity). Phosphorylated by FYN.
Tissue Specificity
Widely expressed in hematopoietic cells but not in other cell types.
Alternative names
VAV, VAV1, Proto-oncogene vav
Database links
swissprot:P15498 omim:164875 omim:605541 omim:600428 swissprot:P52735 swissprot:Q9UKW4 entrezGene:10451 entrezGene:7409 entrezGene:7410