VBP1
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Sequence Similarities
Belongs to the prefoldin subunit alpha family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Nucleus
- In complex with VHL can translocate to the nucleus.
Alternative names
PFDN3, VBP1, Prefoldin subunit 3, HIBBJ46, von Hippel-Lindau-binding protein 1, VBP-1, VHL-binding protein 1