Vcam1

Function

Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.

Post-translational modifications

Cleaved by the metalloproteinase ADAM17 to generate the soluble form.

Sialoglycoprotein.

Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination; leading to proteasomal degradation.

Tissue Specificity

Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.

Cellular localization

• Vascular cell adhesion protein 1
• Cell membrane
• Single-pass type I membrane protein
• Soluble Vascular Cell Adhesion Molecule-1
• Secreted

Alternative names

CD106, Vcam-1, Vcam1, Vascular cell adhesion protein 1, V-CAM 1, VCAM-1

Database links

swissprot:P29533 entrezGene:22329

Other research areas

• Cardiovascular
• Neuroscience