VCAM1

Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.

Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation (PubMed:31310649). Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins (PubMed:10209034). During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration (PubMed:22970700). Serves also as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation (PubMed:35210567).

Cleaved by the metalloproteinase ADAM17 to generate the soluble form.

Sialoglycoprotein.

Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination; leading to proteasomal degradation.

Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.

• Vascular cell adhesion protein 1
• Cell membrane
• Single-pass type I membrane protein
• Soluble Vascular Cell Adhesion Molecule-1
• Secreted

CD106, Vascular cell adhesion protein 1, V-CAM 1, VCAM-1, INCAM-100, VCAM1

• entrezGene:7412
• genbank:NP_001069.1
• genbank:NP_001186763.1
• omim:192225
• swissprot:P19320

Proteins

Immunology & Infectious Disease

• Cardiovascular
• Neuroscience

81276Da