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VCAM1
Domain
Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Function
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Post-translational modifications
Sialoglycoprotein.
Tissue specificity
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
- Vascular cell adhesion protein 1
- V-CAM 1
- VCAM-1
- INCAM-100
- VCAM1
Target type
Proteins
Primary research area
Immunology & Infectious Disease
Other research areas
- Cardiovascular
- Neuroscience
Molecular weight
81276Da