VEGFA

Function

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).

Sequence Similarities

Belongs to the PDGF/VEGF growth factor family.

Alternative names

VEGF, VEGFA, Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF

Database links

swissprot:P50412 entrezGene:443103

Other research areas

• Cardiovascular
• Immuno-oncology
• Neuroscience