VEGFA

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).

Belongs to the PDGF/VEGF growth factor family.

• Secreted
• Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

VEGF, VEGFA, Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF

• swissprot:Q9MYV3

Proteins

Oncology

• Cardiovascular
• Immuno-oncology
• Neuroscience

25175Da