Vegfb
Function
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults.
Post-translational modifications
VEGF-B186 is O-glycosylated.
Sequence Similarities
Belongs to the PDGF/VEGF growth factor family.
Tissue Specificity
Abundantly expressed in heart, brain, kidney and skeletal muscle.
Cellular localization
- Secreted
- Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Alternative names
Vrf, Vegfb, Vascular endothelial growth factor B, VEGF-B, VEGF-related factor, VRF