VISTA_HUMAN

Function

Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993). May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity). May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).

Post-translational modifications

At the cell surface, may be cleaved by MMP14.

N-glycosylated.

Tissue specificity

Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

• C10orf54
• SISP1
• VISTA
• PP2135
• UNQ730/PRO1412
• PP2135
• VSIR
• UNQ730/PRO1412
• VISTA
• SISP1
• C10orf54
• V-type immunoglobulin domain-containing suppressor of T-cell activation
• Platelet receptor Gi24
• Stress-induced secreted protein-1
• V-set domain-containing immunoregulatory receptor
• V-set immunoregulatory receptor
• Sisp-1

Database links

• entrezGene:64115
• omim:615608
• swissprot:Q9H7M9

Target type

Proteins

Primary research area

Immuno-oncology

Molecular weight

33908Da