VMA1

Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:18055462, PubMed:2139027). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:18055462, PubMed:2139027).

PI-SceI is an endonuclease that can cleave at a site present in a VMA1 allele that lacks the derived endonuclease segment of the open reading frame; cleavage at this site only occurs during meiosis and initiates 'homing', a genetic event that converts a VMA1 allele lacking VDE into one that contains it.

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.

Belongs to the ATPase alpha/beta chains family.

• Endomembrane system
• Peripheral membrane protein
• Cytoplasmic side
• Vacuole membrane
• Peripheral membrane protein
• Cytoplasmic side
• Membranes of various intracellular acidic compartments.

CLS8, TFP1, YDL185W, D1286, VMA1, V-type proton ATPase catalytic subunit A, V-ATPase subunit A, Vacuolar proton pump subunit A

• swissprot:P17255

Proteins

118637Da