VNN2
Function
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine (PubMed:11491533). Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
Sequence Similarities
Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.
Tissue Specificity
Widely expressed with higher expression in spleen and blood.
Cellular localization
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
Pantetheine hydrolase VNN2, Glycosylphosphatidyl inositol-anchored protein GPI-80, Protein FOAP-4, Vascular non-inflammatory molecule 2, Vanin-2, VNN2