VPH1

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:11278748, PubMed:1491220, PubMed:8798414). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:11278748, PubMed:1491220). Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:11278748, PubMed:8798414).

Glycosylated.

Belongs to the V-ATPase 116 kDa subunit family.

• Vacuole membrane
• Multi-pass membrane protein

YOR270C, VPH1, V-ATPase a 1 subunit, V-ATPase 95 kDa subunit, Vacuolar pH protein 1, Vacuolar proton pump a subunit, Vacuolar proton translocating ATPase subunit a 1

• entrezGene:854444
• swissprot:P32563

Proteins

95529Da