VPS37C
Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Post-translational modifications
Phosphorylated by TBK1.
Sequence Similarities
Belongs to the VPS37 family.
Cellular localization
- Late endosome membrane
- Peripheral membrane protein
- Probably associates with membranes. Recruited to the plasma membrane by HIV-1.
Alternative names
PML39, VPS37C, Vacuolar protein sorting-associated protein 37C, hVps37C, ESCRT-I complex subunit VPS37C