VPS72
Function
Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.
Post-translational modifications
Phosphorylation is enhanced by ZNHIT1 and promotes the interaction of VPS72 with histone H2AZ1.
Sequence Similarities
Belongs to the VPS72/YL1 family.
Cellular localization
- Nucleus
Alternative names
TCFL1, YL1, VPS72, Vacuolar protein sorting-associated protein 72 homolog, Protein YL-1, Transcription factor-like 1