VRK3
Function
Plays a role in the regulation of the cell cycle by phosphorylating the nuclear envelope protein barrier-to-autointegration factor/BAF that is required for disassembly and reassembly, respectively, of the nuclear envelope during mitosis (PubMed:25899223). Under normal physiological conditions, negatively regulates ERK activity along with VHR/DUSP3 phosphatase in the nucleus, causing timely and transient action of ERK. Stress conditions activate CDK5 which phosphorylates VRK3 to increase VHR phosphatase activity and suppress prolonged ERK activation that causes cell death (PubMed:27346674). For example, upon glutamate induction, promotes nuclear localization of HSP70/HSPA1A to inhibit ERK activation via VHR/DUSP3 phosphatase (PubMed:27941812).
Post-translational modifications
Phosphorylated at Ser-108 by CDK5; leading to protection of the cell against H2O2-induced apoptosis.
Ubiquitinated by RNF144A.
Sequence Similarities
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.
Cellular localization
- Nucleus
- Cytoplasm
- Under oxidative stress, migrates from the nucleus to the cytoplasm.
Alternative names
Serine/threonine-protein kinase VRK3, Vaccinia-related kinase 3, VRK3