VSIG4
Function
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
Tissue Specificity
Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CRIg, Z39IG, UNQ317/PRO362, VSIG4, V-set and immunoglobulin domain-containing protein 4, Protein Z39Ig