VSTM1
Domain
Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. Both motives are required for full inhibition of FCER1A-mediated degranulation.
Function
Isoform 2
Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17).
Isoform 1
Inhibitory immune receptor involved in the regulation of phagocytes.
Post-translational modifications
Isoform 2 is N-glycosylated.
Tissue Specificity
Expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells.
Cellular localization
- Isoform 1
- Membrane
- Single-pass membrane protein
- Isoform 2
- Secreted
Alternative names
UNQ3033/PRO9835, VSTM1, V-set and transmembrane domain-containing protein 1, Signal inhibitory receptor on leukocytes-1, SIRL-1