VSTM2A
Developmental stage
Expressed early in fetal white adipose tissues from 17 to 21 weeks of gestation (at protein level).
Function
Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway.
Post-translational modifications
N-glycosylated. N-linked glycosylation is critical for secretion but not for preadipocyte cell differentiation activity.
Cellular localization
- Secreted
- Secreted by adipose precursor cells (By similarity). Not detected in the nucleus (PubMed:28052263).
Alternative names
VSTM2, VSTM2A, V-set and transmembrane domain-containing protein 2A