VTA1
Function
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR (By similarity). Involved in HIV-1 budding.
Sequence Similarities
Belongs to the VTA1 family.
Cellular localization
- Cytoplasm
- Endosome membrane
- Peripheral membrane protein
Alternative names
C6orf55, HSPC228, My012, VTA1, Vacuolar protein sorting-associated protein VTA1 homolog, Dopamine-responsive gene 1 protein, LYST-interacting protein 5, SKD1-binding protein 1, DRG-1, LIP5, SBP1