B7H4

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

N-glycosylated.

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus.

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Expressed at the cell surface. A soluble form has also been detected.

B7h4, Vtcn1, V-set domain containing T-cell activation inhibitor 1, B7 homolog 4, Immune costimulatory protein B7-H4, Protein B7S1, T cell costimulatory molecule B7x, B7-H4

• entrezGene:242122
• swissprot:Q7TSP5

Proteins

Immuno-oncology

30875Da