Von Willebrand Factor

The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

All cysteine residues are involved in intrachain or interchain disulfide bonds.

N- and O-glycosylated.

Plasma. Expressed in liver.

• Secreted
• Secreted
• Extracellular space
• Extracellular matrix
• Localized to storage granules.

von Willebrand factor, vWF, Vwf

• entrezGene:22371
• swissprot:Q8CIZ8

Proteins

Cardiovascular

• Oncology

309269Da