Vwf

Domain

The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.

Function

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

Post-translational modifications

All cysteine residues are involved in intrachain or interchain disulfide bonds.

N- and O-glycosylated.

Tissue Specificity

Plasma. Expressed in liver.

Cellular localization

• Secreted
• Secreted
• Extracellular space
• Extracellular matrix
• Localized to storage granules.

Alternative names

von Willebrand factor, vWF, Vwf

Database links

swissprot:Q8CIZ8 entrezGene:22371

Other research areas

• Oncology