WASF2/WAVE2

Binds and activates the Arp2/3 complex via the C-terminal domain. Interacts with actin via the WH2 domain.

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.

Belongs to the SCAR/WAVE family.

Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.

• Cytoplasm
• Cytoskeleton
• Cell projection
• Lamellipodium
• Basolateral cell membrane
• At the interface between the lamellipodial actin meshwork and the membrane.

WAVE2, WASF2, Actin-binding protein WASF2, Protein WAVE-2, Verprolin homology domain-containing protein 2, Wiskott-Aldrich syndrome protein family member 2, WASP family protein member 2

• entrezGene:10163
• omim:605875
• swissprot:Q9Y6W5

Proteins

Oncology

54284Da