Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.
Belongs to the SCAR/WAVE family.
Expressed in ovary and brain.
KIAA0900, SCAR3, WAVE3, WASF3, Actin-binding protein WASF3, Protein WAVE-3, Verprolin homology domain-containing protein 3, Wiskott-Aldrich syndrome protein family member 3, WASP family protein member 3
Proteins
Oncology
55293Da
We found 7 products in 3 categories
ab110739
ab272893
ab161165