WASF3
Domain
Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
Function
Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
Post-translational modifications
Phosphorylation by ABL1 promotes lamellipodia formation and cell migration.
Sequence Similarities
Belongs to the SCAR/WAVE family.
Tissue Specificity
Expressed in ovary and brain.
Cellular localization
- Cytoplasm
- Cytoskeleton
Alternative names
KIAA0900, SCAR3, WAVE3, WASF3, Actin-binding protein WASF3, Protein WAVE-3, Verprolin homology domain-containing protein 3, Wiskott-Aldrich syndrome protein family member 3, WASP family protein member 3