WDFY4
Function
Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Also plays a role in B-cell survival through regulation of autophagy.
Cellular localization
- Early endosome
- Endoplasmic reticulum
Alternative names
C10orf64, KIAA1607, WDFY4, WD repeat- and FYVE domain-containing protein 4