WDR5

Function

Contributes to histone modification (PubMed:16600877, PubMed:16829960, PubMed:19103755, PubMed:19131338, PubMed:19556245, PubMed:20018852). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).

Sequence Similarities

Belongs to the WD repeat WDR5/wds family.

Cellular localization

• Nucleus

Alternative names

BIG3, WDR5, WD repeat-containing protein 5, BMP2-induced 3-kb gene protein

Database links

swissprot:P61964 omim:609012 swissprot:Q03164 swissprot:Q9UBL3 entrezGene:4297 entrezGene:9070 entrezGene:5929 entrezGene:11091 swissprot:Q15291 omim:600697 omim:604782 omim:159555