Wdr62
Function
Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (By similarity). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity).
Tissue Specificity
Prominent in neural crest lineages from 9.5 dpc to 11.5 dpc. Also expressed in the ventricular and subventricular zones during the period of cerebral cortical neurogenesis (11.5-16.5 dpc), with expression decreasing in intensity by 17.5 dpc. In the cerebellum, it is strongly expressed in precursors of granule neurons at late embryonic and early postnatal stages; by postnatal day 9 (P9). Present in fetal brain, enriched within the ventricular and subventricular zone (at protein level).
Cellular localization
- Nucleus
- Cytoplasm
- Cytoskeleton
- Spindle pole
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Centriole
- Shows cell cycle-dependent localization. Accumulates to the spindle pole during mitosis (By similarity). Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (By similarity).
Alternative names
WD repeat-containing protein 62, Wdr62