wee1
Function
Protein kinase that acts both on serines and on tyrosines. It acts as a dosage-dependent negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2.
Post-translational modifications
Phosphorylated in the C-terminal by NIM1/CDR1.
Sequence Similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Cellular localization
- Nucleus
Alternative names
SPCC18B5.03, wee1, Mitosis inhibitor protein kinase wee1, P107 protein kinase homolog