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WEE1
Function
Protein kinase that acts both on serines and on tyrosines. It acts as a dosage-dependent negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2.
Post-translational modifications
Phosphorylated in the C-terminal by NIM1/CDR1.
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Cellular localization
- Nucleus
Alternative names
- Mitosis inhibitor protein kinase wee1
- P107 protein kinase homolog
- wee1
- SPCC18B5.03
Database links
Target type
Proteins
Primary research area
Immuno-oncology
Molecular weight
96261Da