WEE2
Function
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).
Involvement in disease
Oocyte/zygote/embryo maturation arrest 5
OZEMA5
An autosomal recessive infertility disorder characterized by oocyte inability to exit metaphase II, resulting in fertilization failure.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Phosphorylated on serine residues (PubMed:29606300). Phosphorylation leads to increase its activity (By similarity).
Sequence Similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Tissue Specificity
Expressed in oocytes (at protein level) (PubMed:29606300). May also be expressed in testis (PubMed:11029659).
Cellular localization
- Nucleus
Alternative names
WEE1B, WEE2, Wee1-like protein kinase 2, Wee1-like protein kinase 1B, Wee1B kinase