Wfs1
Function
Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (By similarity). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (By similarity).
Tissue Specificity
Highly expressed in the developing lens.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Cytoplasmic vesicle
- Secretory vesicle
- Co-localizes with ATP6V1A in the secretory granules in neuroblastoma cell lines.
Alternative names
Wolframin, Wfs1