WIPF1
Domain
Binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site.
Function
Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
Involvement in disease
Wiskott-Aldrich syndrome 2
WAS2
An immunodeficiency disorder characterized by eczema, thrombocytopenia, recurrent infections, defective T-cell proliferation, and impaired natural killer cell function.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the verprolin family.
Tissue Specificity
Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.
Cellular localization
- Cytoplasmic vesicle
- Cytoplasm
- Cytoskeleton
- Cell projection
- Ruffle
- Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear and cortical areas like WASL (By similarity).
Alternative names
WASPIP, WIP, WIPF1, WAS/WASL-interacting protein family member 1, Protein PRPL-2, Wiskott-Aldrich syndrome protein-interacting protein, WASP-interacting protein