WNT10B

Developmental stage

Infant brain has higher levels of WNT10B than adult brain.

Function

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin.

Involvement in disease

Split-hand/foot malformation 6

SHFM6

A limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting.

None

The disease is caused by variants affecting the gene represented in this entry.

Tooth agenesis, selective, 8

STHAG8

A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). STHAG8 inheritance is autosomal dominant.

None

The disease is caused by variants affecting the gene represented in this entry. Potential genotype-phenotype correlation between variants and the positions of missing teeth.

Post-translational modifications

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Sequence similarities

Belongs to the Wnt family.

Tissue specificity

Detected in most adult tissues. Highest levels were found in heart and skeletal muscle. Low levels are found in brain.

Cellular localization

• Secreted
• Extracellular space
• Extracellular matrix
• Secreted

Alternative names

• Protein Wnt-10b
• Protein Wnt-12
• WNT12
• WNT10B

Database links

• entrezGene:7480
• omim:601906
• swissprot:O00744

Target type

Proteins

Primary research area

Oncology

Molecular weight

43000Da